Darwin's Children (30 page)

Liz put her hands on her hips and stood in an attitude of defiant expectation. She pushed back a strand of curly strawberry blonde hair and loudly chewed a wad of gum. Her eyes were bright as drops of fresh blue ink. “He says we’re removing necessary transcription factors surrounding our ERV targets, throwing out the baby with the contaminated bathwater.”

“A lot of those factors are transactivated by ERV. You can’t have it both ways, Dr. Jackson. Well, at least we can shoot that one down.” Kaye slumped on a stool. “We’re not getting anywhere,” she muttered. “We’re taking out the viruses and not getting any baby chimps. What does it take for him to come around?” She glanced up at Liz, who was still waggling her hips and snapping her chewing gum in mock defiance of La Robert.

Liz cracked a big sappy smile. “Feel better?”

Kay shook her head and laughed despite herself. “You look like a Broadway gamine. Who are you supposed to be, Bernadette Peters?”

Liz cocked her hips and fluffed her hair with one hand. “She’s a corker. Which play?” she demanded. “Revival of
Mame
?”

“Sweeney Todd,”
Kaye said.

“That would be Winona Ryder,” Liz countered.

Kaye groaned. “Where do you get so much energy?”

“Bitterness. Seriously, how did it go?”

“I’m being used as a prop by one side and a patsy by the other. I feel like Dorothy in the tornado.”

“Sorry,” Liz said.

Kaye stretched and felt her back pop. Mitch used to do that for her. She riffled through Jackson’s folder again and found the page that through instinct, and a touch of luck, had caught her eye a moment before: suspect lab protocols.

As ever, Jackson was trapped in a maze of in vitro studies—test-tube and petri dish blind alleys using Tera2 tumor cell lines—proven traps for making mistakes with ERV.
Hell, he’s even using chicken embryos,
she thought.
Egglayers don’t use ERVs the same way we do.

“Jackson’s vaccines kill monkeys,” Kaye said softly, tapping the page. “Marge doesn’t like projects that never get past animal studies.”

“Shall we play another game of Gotcha with Dr. Jackson?” Liz asked innocently.

“Sure,” Kaye said. “I am almost cheered by this.” She dropped the folder on her small, crowded desk.

“I’m off to check our arrays, and then I’m going home,” Liz called out as she pushed through the door with the tray. “I’ve been working all night. You in for the week?”

“Until they fire me,” Kaye said. She rubbed her nose reflexively. “I need to look over the fragile site studies from last week.”

“Prepped and digitized. They’re on the photobase,” Liz said. “There’s some leftover spaghetti in the fridge.”

“Heavenly,” Kaye said.

“Bye,” Liz called as the door swung closed behind her.

Kaye got up and rubbed her nose again. It felt slightly stuffy, not unpleasantly so. The lab smelled unusually sweet and fresh, not that it ever smelled dirty. Liz was a stickler for cleanliness.

The scent was hard to place, not at all like perfume or flowers.

There was a long day’s work ahead, preparing for tomorrow’s morning meeting. Kaye closed her eyes, hoping to find her calm spot; she needed to focus on the chromosome results from last week. Get the sour clamp of Washington off her gut.

She pulled the stool over to the workstation and entered her password, then called up the tables and photos of chimpanzee chromosome mutations.

Early-stage embryos modified for lab work had had all of their single-copy ERVs deleted, but all multicopy ERVs, LINEs, and “defective” ERVs left intact. They had then been allowed to develop for forty-eight hours. The chromosomes, bunched up by mitosis, were removed, photographed, and crudely sequenced. What Kaye was looking for were anomalies around fragile sites and hot spots in the chromosomes—regions of genes that responded quickly to environmental change, suggesting rapid adaptive response.

The modified chimp chromosomes were severely distorted—she could tell that just by looking at the photos. The fragile sites were all screwed up, broken and rearranged incorrectly. The embryos would never have implanted in the womb, much less gone to term. Even single-copy ERVs were important to fetal development and chromosome adaptation in mammals, perhaps especially so in primates.

She looked over the analysis and saw random and destructive methylation of genes that should be actively transcribing, necessary lengths of DNA mothballed like a fleet of old ships, curling the chromatin into an agony of alternating misplaced activity and dark, inactive lassitude.

They looked
ugly
, those chromosomes, ugly and unnatural. The early-stage embryos, growing under the tutelage of such chromosomes, would die. That was the story of everything they had done in the lab. If, by rare chance, the ERV-knockout embryos managed to implant and begin development, they were invariably resorbed within the first few weeks. And getting that far had required giving the chimp mothers massive drug regimens developed for human mothers at fertilization clinics to prevent miscarriages.

The ERVs served so many functions in the developing embryos, including mediating tissue differentiation. And it was already obvious that TLV—the Temin-Larsson-Villarreal conjecture—was correct. Highly conserved endogenous retroviruses expressed by the trophectoderm of the developing embryo—the portion that would develop into the surrounding amnion and placenta—protected against attacks by the mother’s immune system. The viral envelope proteins selectively subdued the mother’s immune response to her fetus without weakening the mother’s defenses against external pathogens, an exquisite dance of selectivity.

Because of the protective function of legacy retroviruses, ERV knockout—the removal or stifling of most or all of the genome’s “original sins”—was invariably fatal.

Kaye vividly remembered the chill she had felt when Mitch’s mother had described SHEVA as “original sin.” How long ago had that been—fifteen years? Just after they had conceived Stella.

If SHEVA and other ERV constituted original sin, then it was starting to look as if all placental mammals, perhaps all multicelled life forms, were filled with original sin, required it, died without it.

And wasn’t that what the Garden of Eden was all about? The beginning of sex and self-knowledge and life as we know it.

All because of viruses.

“The hell with that,” Kaye muttered. “We need a new name for these things.”

12

ARIZONA

R
oll call was Stella’s least favorite time of day, when the girls were all gathered together and Miss Kantor walked between the rows under the big tent.

Stella sat cross-legged and drew little figures of flowers and birds in the dust with her finger. The canvas flapped with the soft morning breeze. Miss Kantor walked between the lines of seated, cross-legged adolescents and leafed through her daybook. She relied entirely on paper, simply because losing an e-pad or laptop in the reserve was a severe offense, punishable by dismissal.

The dormitories held no phones, no satellite feeds, no radios. Television was limited to educational videos. Stella and most of the other children here had come to abhor television.

“Ellie Ann Garcia.”

“Here.”

“Stella Nova Rafelson.”

“Here,” Stella called out, her voice silvery in the cool desert air.

“How’s your cold, Stella?” Miss Kantor asked as she walked down the row.

“Done,” Stella answered.

“Eight days, wasn’t it?” Miss Kantor tapped her pen on the daybook page.

“Yes, ma’am.”

“That’s the fifth wave of colds we’ve had this year.”

Stella nodded. The counselors kept careful and tedious track of all infections. Stella had spent several hours being examined, five days ago; so had two dozen other children with similar colds.

“Kathy Chu.”

“Here!”

Miss Kantor walked by Stella again after she had finished. “Stella, are you scenting?”

Stella looked up. “No, Miss Kantor.”

“My little sensor tells me you are.” She tapped the nosey on her belt. Stella was not scenting, and neither was anybody around her. Miss Kantor’s electronic snitch was wrong, and Stella knew why; Miss Kantor was having her period and that could confuse the nosey. But Stella would never tell her that.

Humans hated to be clued when they produced revealing odors.

“You’ll never learn to live in the outside world if you can’t control yourself,” Miss Kantor said to Stella, and knelt in front of her. “You know the rules.”

Stella got to her feet without being prompted. She did not know why she was being singled out. She had done nothing unusual.

“Wait over by the truck,” Miss Kantor said.

Stella walked to the truck, brilliant white under the morning sun. The air over the mountains was intense and blue. It was going to be hot in a few hours, but it might rain heavily later; that would make the late-afternoon air perfect for catching up. She did not want to miss that.

Miss Kantor finished her count and the kids filed off to the morning classes in the trailers and bungalows scattered over the dusty grounds. The counselor and her assistant, a quiet, plump young woman named Joanie, walked across the gravel to the truck. Miss Kantor would not look straight at Stella.

“I know it wasn’t just you,” Miss Kantor said. “But you’re the only one I could catch. It has to stop, Stella. But I’m not going to punish you this time.”

“Yes, ma’am.” Stella knew better than to argue. When things went her way, Miss Kantor was reasonable and fairly easygoing, but any show of defiance or contradiction and she could get harsh. “Can I go to classes now?”

“Not yet,” Miss Kantor said, placing her notepad in the truck. She opened the rear door of the truck. “Your father is visiting,” she said. “We’re going back to the infirmary.”

Stella sat in the back of the truck, behind the plastic barrier, feeling confused. Miss Kantor climbed into the front seat. Joanie closed the door for her and went back to the tent. “Is he there, now?” Stella asked.

“He’ll arrive in an hour or so,” Miss Kantor said. “You two just got approval. That’s pretty good, isn’t it?”

“What do they want?” Stella asked suddenly, before she could control her tongue.

“Nothing. It’s a family visit.”

Miss Kantor switched on the truck motor. Stella could feel her disapproval. Parental visits were futile at the best of times, Miss Kantor believed. The children would never be fully integrated into human society, no matter what the school policy said. She knew the children too well. They just could not behave appropriately.

Worse still, Miss Kantor knew that Stella’s father had served time in prison for assaulting Emergency Action enforcement officers. Having him as a visitor would be something of an affront to her. She was a holdover from the times when Sable Mountain School had been a prison.

Stella had not seen Mitch in three years. She hardly remembered what he smelled like, much less what he looked like.

Miss Kantor drove over the gravel to the paved road, and then between the brush half a mile to the brick building they called the hospital. It wasn’t really a hospital. As far as Stella knew, for sure, the hospital was just the administration and detention center for the school. It had been a hospital once, for the prison. Some kids claimed the hospital was where they injected salt into your cheeks, or resected your tongue, or Botoxed the new facial muscles that made your expressions so compelling.

It was the place they tried to turn SHEVA kids into humans. Stella had never met a kid who had undergone such torments, but that was explained, some said, by the fact that they sent those kids away to Suburbia, a town made up of nothing but SHEVA kids trying to act just like humans.

That was not true, as far as Stella knew, but the hospital was where they sent you when they wanted to draw blood. She had been there many times for that purpose.

There were lots of stories in the camps. Few of them were true, but most were scary, and the kids could get ominously bored.

As they drove through a razor-wire fence and over a moat, Stella felt something sad and cold grow in her.

Memory.

She did not want to lose her focus. She stared through the window, resenting Mitch for coming. Why now? Why not when she had her act together and could tell him she had accomplished something worthwhile? Life was still too confused. The last visit with her mother had been painful. Stella had not known what to say. Her mother had been so sad and full of needs neither could satisfy.

She hoped Mitch would not just sit and stare at her over the table in the family conference room. Or ask pointed questions. Or try to tell Stella there was hope they would get together again. Stella did not think she could stand that.

Stella dipped her head and rubbed her nose. She touched the tip of her finger to the corner of her eye and then to her tongue, out of sight of the rearview mirror. Her eyes were moist and the tears tasted of bitter salt. She would not cry openly, however. Not in front of a human.

Miss Kantor stopped the truck in the parking lot of the flat brick building, got out, and opened Stella’s door. Stella followed her into the hospital. As they turned a corner, through a gap in the brick breezeway she saw a long yellow bus drawn up beside the processing office. A load of new kids had arrived. Stella hung back a few steps from Miss Kantor as they passed through the glass doors and walked to the detention center.

The door to the secretary’s office was always open, and through the wide window beyond, Stella thought she would catch a glimpse of the new kids from the shipment center. That would be something to take back to the deme; possible recruits or news from outside.

Suddenly, irrationally, she hated Mitch. She did not want him to visit. She did not want any distractions. She wanted to focus and never have to worry about humans again. She wanted to lash out at Miss Kantor, strike her down to the linoleum floor, and run away to anywhere but here.

Through Stella’s brief, fierce scowl—a more intense scowl than most humans could manage—she caught a glimpse of the lineup of children beyond the secretary’s window. Her scowl vanished.