Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (1005 page)

Normal In

   Asthma

   Limitations

   A normal level of IgE in serum does not eliminate the possibility of allergic disease.

IMMUNOGLOBULIN G (IgG)

   Definition

   IgG activates complement and fights infection. IgG represents 70–80% of the total serum immunoglobulins in the normal adults. It exists in four subclasses (IgG1, IgG2, IgG3, and IgG4). IgG1 predominates as 65% of the total IgG. IgG of maternal origin provides passive immunity to the neonate. It is transported across the placenta.

   
Normal ranges:
see Table 16.43.

TABLE 16–43. Normal Ranges for IgG by Age

   Use

   Diagnosis of IgG myeloma

   Diagnosis of hereditary and acquired IgG immunodeficiencies

   Serologic diagnosis of infectious diseases and immunity

   Interpretation

Increased In

   Monoclonal

   Multiple myeloma