Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (1253 page)

   Certain drugs (e.g., estrogens, birth control pills, perphenazine, clofibrate, heroin, methadone).

   Estrogen-producing tumors.

   Systemic illness is increased early.

   Acute intermittent porphyria.

   Acute or chronic active hepatitis.

   Lymphocytic painless subacute thyroiditis.

   Neonates.

   Inherited.

   Idiopathic.

   An increased TBG is associated with increased serum T
₄
and decreased T
₃
resin uptake; a converse association exists for decreased TBG.

Decreased In

   Nephrosis and other causes of marked hypoproteinemia such as liver disease, severe illness (late), stress (thyroxine-binding prealbumin [TBPA] also decreased)

   Deficiency of TBG, genetic or idiopathic

   Acromegaly (TBPA also decreased)

   Severe acidosis