Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (726 page)

   Treatment of psychoses, schizophrenia, mania, Tourette syndrome (haloperidol)

   Limitations

   Immunoassay: RIA—nonspecific, semiquantitative due to varying cross-reactivity with parent drug and metabolites.

   Fluorometry: nonspecific, semiquantitative due to interferences from metabolites.

   Hemolyzed specimens are unacceptable. Remove serum from clot as soon as possible.

   Lithium: Lithium heparin and sodium fluoride/potassium oxalate tubes are unacceptable.

ANTISPERM AUTOANTIBODIES–IMMUNOBEAD BINDING TEST
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   Definition

   The immunobead binding test for antisperm antibodies identifies antibodies on sperm cells by immunoglobulin class and general specificity (head, midpiece, and tail) by means of their ability to agglutinate polyacrylamide beads coated with anti-Ig class–specific antibodies.

   
Reference range:
≤20% of sperm cells bound to immunobeads.

   Use

   Confirmation of sperm autoimmunity, as suggested by the presence of agglutinated sperm and/or reduced motility in a semen analysis. Only the IgG and IgA classes of such antibodies are clinically significant.

   Interpretation