Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (945 page)

Decreased In

   Antrectomy with vagotomy

   Hypothyroidism

   Drugs, including anticholinergics and tricyclic antidepressants

   Limitations

   Gastrin levels follow circadian rhythms (lowest in early morning and highest during the day).

   No consistent relationship has been established between
H
.
pylori
and gastric acid secretion or serum gastrin levels.

GAUCHER DISEASE MOLECULAR DNA ASSAY
*

   Definition

   Gaucher disease (GD) molecular DNA testing identifies mutations in the acid β-glucosidase (
GBA
) gene in carriers and affected individuals. Glucosylceramidase enzyme activity is very low in affected individuals, but enzyme assay is not recommended for detection of
GBA
gene mutation carriers. Carrier testing should be accomplished through DNA testing of the
GBA
gene.

   
Normal values:
negative or no mutations are found.

   Use

   
Carrier testing for Ashkenazi Jewish individuals

   
Carrier testing for at-risk family members of affected individuals

   For carrier testing use: