Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (993 page)

   
Uveitis
:

   Acute anterior uveitis:
HLA-B*27
(especially
HLA-B*27:05
).

   Behçet disease:
HLA-B*51
, RR is only 6–10.

   Birdshot chorioretinopathy:
HLA-A*29
(especially with
HLA
-
A*29:02
).

   
Idiopathic membranous glomerulonephritis insulin-dependent (type 1) diabetes mellitus
:

   
HLA - DRB1*03:01-DQA1*05:01-DQB1*02:01; HLA-DRB1*04:01/04:02/04:05-DQA1*03-DQB1*03:02

   
Narcolepsy
:
HLA-DQB1*06:02
allele on the
DRB1*15:01-DQA1*01:02-DQB1*06:02
haplotype. Individuals homozygous for
HLA-DQB1*06:02
have a higher risk of acquiring narcolepsy than individuals heterozygous for this allele. Heterozygous with
HLA
-
DQB1*03:01
,
HLA-DQB1*05:01
, and
-DQB1*06:01
are thought to be protective.

   
Rheumatoid arthritis
:

   
HLA-DRB1*04:01/04:04/04:05/04:08, -DRB1*01:01
Caucasian;
HLA-DRB1*04:05
Japanese;
HLA-DRB1*14:02
American Indian

   
HLA and drug sensitivities/side effects
:

   The reverse transcriptase inhibitor,
abacavir
and
HLA-B*57:01
, the gout prophylactic,
allopurinol
and
HLA-B*58:01
, and the antiepileptic,
carbamazepine
and
HLA
-
B*15:02

Suggested Readings

Bharadwaj M, Illing P, Kostenko L. Personalized medicine for HLA-associated drug-hypersensitivity reactions.
Pers Med.
2010;7(5):495–516.

de Bakker PIW, McVean G, Sabeti PC, et al. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
Nat Genet.
2006;38(10):1166–1172.

HLA Association of autoimmunity and infectious diseases Poster by Texas BioGene, 2008.

http://www.uptodate.com/contents/human-leukocyte-antigens-hla-a-roadmap

Raychaudhuri S, Sandor C, Stahl EA, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
Nat Genet.
2012;44:291.