The Coming Plague (113 page)
Authors: Laurie Garrett
The planet is nothing but a crazy quilt of micro soups scattered all over its 196,938,800-square-mile surface.
We, as individuals, can't see them, or sense their presence in any useful manner. The most sophisticated of their species have the ability to outwit or manipulate the one microbial sensing system
Homo sapiens
possess: our immune systems. By sheer force of numbers they overwhelm us. And they are evolving far more rapidly than
Homo sapiens,
adapting to changes in their environments by mutating, undergoing high-speed natural selection,
or drawing plasmids and transposons from the vast mobile genetic lending library in their environments.
Homo sapiens
possess: our immune systems. By sheer force of numbers they overwhelm us. And they are evolving far more rapidly than
Homo sapiens,
adapting to changes in their environments by mutating, undergoing high-speed natural selection,
or drawing plasmids and transposons from the vast mobile genetic lending library in their environments.
Further, every microscopic pathogen is a parasite that survives by feeding off a higher organism. The parasites are themselves victims of parasitism. Like a Russian wooden doll-within-a-doll, the intestinal worm is infected with bacteria, which are infected with tiny phage viruses. The whale has a gut full of algae, which are infected with
Vibrio cholerae
. Each microparasite is another rivet in the Global Village airplane. Interlocked in sublimely complicated networks of webbed systems, they constantly adapt and change. Every individual alteration can change an entire system; each systemic shift can propel an interlaced network in a radical new direction.
Vibrio cholerae
. Each microparasite is another rivet in the Global Village airplane. Interlocked in sublimely complicated networks of webbed systems, they constantly adapt and change. Every individual alteration can change an entire system; each systemic shift can propel an interlaced network in a radical new direction.
In this fluid complexity human beings stomp about with swagger, elbowing their way without concern into one ecosphere after another. The human race seems equally complacent about blazing a path into a rain forest with bulldozers and arson or using an antibiotic “scorched earth” policy to chase unwanted microbes across the duodenum. In both macro- and microecology, human beings appear, as Harvard's Dick Levins put it, “utterly incapable of embracing complexity.”
Only by appreciating the fine nuances in their ecologies can human beings hope to understand how their actions, on the macro level, affect their micro competitors and predators.
Time is short.
As the
Homo sapiens
population swells, surging past the 6 billion mark at the millennium, the opportunities for pathogenic microbes multiply. If, as some have predicted, 100 million of those people might then be infected with HIV, the microbes will have an enormous pool of walking immune-deficient petri dishes in which to thrive, swap genes, and undergo endless evolutionary experiments.
Homo sapiens
population swells, surging past the 6 billion mark at the millennium, the opportunities for pathogenic microbes multiply. If, as some have predicted, 100 million of those people might then be infected with HIV, the microbes will have an enormous pool of walking immune-deficient petri dishes in which to thrive, swap genes, and undergo endless evolutionary experiments.
“We are in an eternal competition. We have beaten out virtually every other species to the point where we may now talk about protecting our former predators,” Joshua Lederberg told a 1994 Manhattan gathering of investment bankers.
67
“But we're not alone at the top of the food chain.”
67
“But we're not alone at the top of the food chain.”
Our microbe predators are adapting, changing, evolving, he warned. “And any more rapid change would be at the cost of human devastation.”
The human world was a very optimistic place on September 12, 1978, when the nations' representatives signed the Declaration of Alma Ata. By the year 2000 all of humanity was supposed to be immunized against most infectious diseases, basic health care was to be available to every man, woman, and child regardless of their economic class, race, religion, or place of birth.
But as the world approaches the millennium, it seems, from the microbes' point of view, as if the entire planet, occupied by nearly 6 billion mostly impoverished
Homo sapiens,
is like the city of Rome in 5 B.C.
Homo sapiens,
is like the city of Rome in 5 B.C.
“The world really is just one village. Our tolerance of disease in any place in the world is at our own peril,” Lederberg said. “Are we better off
today than we were a century ago? In most respects, we're worse off. We have been neglectful of the microbes, and that is a recurring theme that is coming back to haunt us.”
today than we were a century ago? In most respects, we're worse off. We have been neglectful of the microbes, and that is a recurring theme that is coming back to haunt us.”
In the end, it seems that American journalist I. F. Stone was right when he said, “Either we learn to live together or we die together.”
While the human race battles itself, fighting over ever more crowded turf and scarcer resources, the advantage moves to the microbes' court. They are our predators and they will be victorious if we,
Homo sapiens,
do not learn how to live in a rational global village that affords the microbes few opportunities.
Homo sapiens,
do not learn how to live in a rational global village that affords the microbes few opportunities.
It's either that or we brace ourselves for the coming plague.
In the summer of 1993, Ron MacKenzie, now comfortably retired in a southern California desert community, was watching the evening news on television. A brief story caught his attention. It concerned shifts from agricultural production to growing coca plants for cocaine in various regions of Latin America, and MacKenzie recognized the place depicted. It was his beloved San JoaquÃn, Bolivia.Viewing footage of the old cow town transported the retired physician back to a time when he was a strapping, though naïve, physician in Sausalito, California. And to that day in 1962 in La Paz when the Bolivian Minister of Health asked if he would mind taking a look at a mysterious
typho negro
outbreak deep in the Bolivian interior.
typho negro
outbreak deep in the Bolivian interior.
MacKenzie sat in his living room for a few moments, recalling the terror that struck Bolivia's Machupo River region when the strange hemorrhagic fever swept through. And he wondered how, after the passage of thirty years, the people had fared.
He reached for his telephone and called Montana. Karl Johnson, also long retired and living the way he preferred, in rugged cowboy country surrounded by prime trout-fishing streams, answered the phone. The old colleagues resolved to revisit San JoaquÃn.
MacKenzie, recalling the difficulties involved in reaching the remote area during the 1960s, called a colleague in La Paz for transportation advice, and made arrangements for a September trip. MacKenzie told the colleague that he and Johnson just wanted to have a little look-see after all these years.
For several months a new outbreak of Bolivian hemorrhagic fever had been raging in areas near San JoaquÃn, and CDC investigators had assisted the government in proving that the Machupo virus had made a comeback. Once again, for the first time in thirty years, Bolivia was waging an aggressive mouse control campaign in the region. That, too, piqued Johnson and MacKenzie's interest.
When the Americans arrived in La Paz, they were surprised by their warm, high-level reception. Thirty years was a long timeâneither of them expected anyone to remember their efforts so long ago in the remote savanna
region. But ceremonies, praise, and medals were lavished on the stunned scientists during their days in the capitalâso much so that their journey to San JoaquÃn was delayed by nearly forty-eight hours.
region. But ceremonies, praise, and medals were lavished on the stunned scientists during their days in the capitalâso much so that their journey to San JoaquÃn was delayed by nearly forty-eight hours.
Finally, the government arranged for a plane to fly the pair of scientists to the remote region, and MacKenzie reexperienced the dizzying ascent from the mile-high city, the passage through the Andes, and the descent into the steamy headlands of the Amazon.
As the plane approached San JoaquÃn, Johnson and MacKenzie wondered what was going on: there seemed to be quite a crowd gathered around the airstrip. When they landed, MacKenzie asked if their trip might be coinciding with the arrival of some dignitary or politician.
The moment they stepped out of the aircraft, a local marching band struck up a stirring tune and more than 300 peasants, cowboys, children, and farmers cheered the Americans. MacKenzie and Johnson were overwhelmed by the exuberant, joyous crowd, the hugs and handshakes, the flowers and gifts. Neither man could believe that the people of San JoaquÃn recognized them, or remembered their search, so long ago, for the source of Bolivia's plague.
“Most of these people weren't even alive back then,” MacKenzie said to Johnson, who shared his sense of amazement.
But for the people of San JoaquÃn the names of MacKenzie, Kuns, Johnson, and Webb were emblazoned permanently on their cultural memory. Streets, some of which were now paved, were named after the near-mythic heroes from North America who had spared San JoaquÃn from doom. Even the schoolchildren knew who the white-haired “disease cowboys” were.
These were the men who stopped their plague.
And that was why for more than forty-eight hours the people of San JoaquÃn had waited patiently through the intermittent rain, standing on the landing strip and staring hopefully into the western sky.
Introduction
1
R. M. Krause. Washington, D.C.: National Foundation for Infectious Diseases, 1981.
2
R. M. Krause, Foreword to S. S. Morse, ed.,
Emerging Viruses
(Oxford, Eng.: Oxford University Press, 1993).
Emerging Viruses
(Oxford, Eng.: Oxford University Press, 1993).
3
J. Lederberg, R. E. Shope, and S. C. Oaks, Jr., Washington, D.C.: National Academy Press, 1992.
4
E. O. Wilson,
The Diversity of Life
(Cambridge, MA: Harvard University Press, 1992). 31.
The Diversity of Life
(Cambridge, MA: Harvard University Press, 1992). 31.
5
A. Gore,
Earth in the Balance
(New York: Houghton Mifflin, 1992).
Earth in the Balance
(New York: Houghton Mifflin, 1992).
6
J. Lederberg, “Medical Science, Infectious Disease, and the Unity of Mankind,”
Journal of the American Medical Association
260 (1988): 684â85; and Institute of Medicine,
Emerging Infections: Microbial Threats to Health in the United States
(Washington, D.C.: National Academy Press. 1992).
Journal of the American Medical Association
260 (1988): 684â85; and Institute of Medicine,
Emerging Infections: Microbial Threats to Health in the United States
(Washington, D.C.: National Academy Press. 1992).
1. Machupo
1
K. M. Johnson, et al., “Virus Isolations from Human Cases of Hemorrhagic Fever in Bolivia.”
Proceedings of the Society of Experimental Biology and Medicine
118 (1965): 113â18.
Proceedings of the Society of Experimental Biology and Medicine
118 (1965): 113â18.
2
H. W. Lee, “Korean Hemorrhagic Fever,” in S. R. Pattyn, ed.,
Ebola Virus Hemorrhagic-Fever
(Amsterdam: Elsevier Press, 1978), 331â43.
Ebola Virus Hemorrhagic-Fever
(Amsterdam: Elsevier Press, 1978), 331â43.
3
R. G. Gordon, et al., “Bolivian Hemorrhagic Fever Probably Transmitted by Personal Contact,”
American Journal of Epidemiology
82 (1965): 85â91.
American Journal of Epidemiology
82 (1965): 85â91.
4
Several years later Kuns would toil over insect samples he collected in San JoaquÃn and discover that a species of soft tick.
Ornithodoros boliviensis,
carried a virus. It was not, however, the virus responsible for the human epidemic. Nor did it match any other type of South American virus. So Kuns dubbed his new microbe Matucare virus, after a stream near San JoaquÃn. He showed the virus was lethal for baby mice and guinea pigs but harmless to human beings. Matucare virus would never have been discovered had there not been a human disease outbreak near the habitat of the
0. boliviensis
tick.
Ornithodoros boliviensis,
carried a virus. It was not, however, the virus responsible for the human epidemic. Nor did it match any other type of South American virus. So Kuns dubbed his new microbe Matucare virus, after a stream near San JoaquÃn. He showed the virus was lethal for baby mice and guinea pigs but harmless to human beings. Matucare virus would never have been discovered had there not been a human disease outbreak near the habitat of the
0. boliviensis
tick.
5
R. B. MacKenzie, P. A. Webb, and K. M. Johnson, “Detection of Complement-Fixing Antibody After Bolivian Hemorrhagic Fever, Employing Machupo, JunÃn and Tacaribe Virus Antigen,”
American Journal of Tropical Medicine and Hygiene
14 (1965): 1079â84; K. M. Johnson et al.. “Isolation of Machupo Virus from Wild Rodent
Calomys callosus,” American Journal of Tropical Medicine and Hygiene
15 (1966): 103â6; P. A. Webb, “Properties of Machupo Virus
,
”
American Journal of Tropical Medicine and Hygiene
14 (1965): 799â801; P. A. Webb et al., “Some Characteristics of Machupo Virus. Causative Agent of Bolivian Hemorrhagic Fever,”
American Journal of Tropical Medicine and Hygiene
16 (1967): 531â38; and K. M. Johnson, “Arenaviruses,” in B. N. Fields et al., eds.,
Virology
(New York: Raven Press, 1985), 1033â53.
American Journal of Tropical Medicine and Hygiene
14 (1965): 1079â84; K. M. Johnson et al.. “Isolation of Machupo Virus from Wild Rodent
Calomys callosus,” American Journal of Tropical Medicine and Hygiene
15 (1966): 103â6; P. A. Webb, “Properties of Machupo Virus
,
”
American Journal of Tropical Medicine and Hygiene
14 (1965): 799â801; P. A. Webb et al., “Some Characteristics of Machupo Virus. Causative Agent of Bolivian Hemorrhagic Fever,”
American Journal of Tropical Medicine and Hygiene
16 (1967): 531â38; and K. M. Johnson, “Arenaviruses,” in B. N. Fields et al., eds.,
Virology
(New York: Raven Press, 1985), 1033â53.
The U.S. Army provided logistical support to the ongoing Machupo investigation. In 1964 a Sergeant Lowery got infected and very nearly died of the disease. As had Webb months earlier. Lowery's wife comforted the ailing sergeant and also developed the disease. Lowery's condition was so severe that one Sunday morning the hospital director ordered the Gorgas pathologist put on standby to perform an autopsy. Meanwhile. MacKenzie gave Lowery a pint of his blood, hoping it contained helpful antibodies. Whether or not the antiserum made the difference will never be known, but later that Sunday Lowery started to recover. The sergeant and his wife survived Machupo.
6
A. S. Parodi, et al., “Sobre la Etiologia del Brote Epidémico de JunÃn,”
DÃa Médica
30 (1958): 2300â1.
DÃa Médica
30 (1958): 2300â1.
Jordi Casals, of the Rockefeller Foundation, isolated the actual virus for JunÃn disease. He discovered it closely resembled another mouse virus called LCM (lymphocytic choriomeningitis virus), which he had accidentally stumbled upon in 1958 while studying rabies-infected mouse cells. Casals dubbed LCM. and later JunÃn. Tacaribe, and Machupo, “arenaviruses” because under high-powered microscopes tissues infected with these agents “looked as though they had been sprinkled with sand.” The word “arena” is Latin for sand. In 1964 Casals isolated another new arenavirus from Brazilian mice, dubbed Ampari virus. Fortunately. Ampari proved harmless to human beings. N. Mettler, S. M. Buckley, and J. Casals, “Propagation of JunÃn Virus, the Etiological Agent of Argentine Hemorrhagic Fever, in HeLa Cell Cultures,”
Proceedings of the Society of Experimental Biology and Medicine
107 (1961): 684â88: and F. P. Pinheiro et al., “Amapari, a New Virus of the Tacaribe Group from Rodents and Mites of Amapa Territory, Brazil,”
Proceedings of the Society of Experimental Biology and Medicine
122 (1966): 531â35.
Proceedings of the Society of Experimental Biology and Medicine
107 (1961): 684â88: and F. P. Pinheiro et al., “Amapari, a New Virus of the Tacaribe Group from Rodents and Mites of Amapa Territory, Brazil,”
Proceedings of the Society of Experimental Biology and Medicine
122 (1966): 531â35.
7
Knowing the cause of a disease, even a terrible hemorrhagic one, is only the first step. Despite such knowledge, over 20,000 people have suffered acute JunÃn since its 1958 discovery, and the territory of the virus-carrying mouse has steadily expanded from the Buenos Aires province to, by 1985. three neighboring provinces of Argentina. Case fatality rates in recent outbreaks have been as high as 30 percent of all infected people. After Johnson and his colleagues completed their Machupo work in San JoaquÃn, another outbreak of that disease occurred in Beni, Bolivia, some years later. See World Health Organization. “Viral Haemorrhagic Fevers: Report of a WHO Expert Committee,”
Technical Report Series
721 (1985).
Technical Report Series
721 (1985).
8
In 1972 Machupo broke out again in an area about forty miles from San JoaquÃn. Though details of exactly how the epidemic began remained elusive. Kuns's investigations pointed to the daughter of a wealthy ranchero owner. She apparently got Machupo after visiting her boyfriend, a young man from the village of Magdalena. Magdalena was the first Machupo-plagued town MacKenzie visited nine years earlier, and Kuns has always been convinced the ranchero owner's daughter got infected through sexual contact with a person carrying the virus. Sadly, none of the published accounts of Machupo directly stated the possibility that the virus could be transmitted through sexual intercourse, although official accounts of Webb's illness spelled out the likelihood Machupo could be passed from person to person by a kiss.
9
“The Search for the Invisible Killer,”
Saturday Evening Post
, December 3, 1966: 92â96.
Saturday Evening Post
, December 3, 1966: 92â96.
2. Health Transition
1
A. R. Hinman et al., “Live or Inactivated Poliomyelitis Vaccine: An Analysis of Benefits and Risks.”
American Journal of Public Health
78 (1988): 291â95.
American Journal of Public Health
78 (1988): 291â95.
2
J. A. Najera, “Malaria and the Work of WHO,”
Bulletin of the World Health Organization
67 (1989): 229â43.
Bulletin of the World Health Organization
67 (1989): 229â43.
3
Ibid.
4
J. S. Horn, “
Away with All Pests”: An English Surgeon in People's China: 1954â1969
(London: Modern Reader, 1969).
Away with All Pests”: An English Surgeon in People's China: 1954â1969
(London: Modern Reader, 1969).
5
Schistosomiasis is a deadly intestinal and liver disease caused by parasitic worms. The disease process begins when adult snails insert worm eggs into the bloodstream of a human being who works or plays along the edges of canals, streams, irrigation ditches, or lakes. The eggs grow, becoming worms, or flukes, that reside in the liver.
6
Horn (1969), op. cit.
7
U.S. Department of Health. Education, and Welfare.
Selected Disease Control Programs
(Washington, D.C., 1966).
Selected Disease Control Programs
(Washington, D.C., 1966).
8
U.S. Department of Health, Education, and Welfare.
Study Group on the Mission and Organization of the Public Health Service: Final Report
(Washington. D.C., 1960).
Study Group on the Mission and Organization of the Public Health Service: Final Report
(Washington. D.C., 1960).
9
W. H. Stewart, “A Mandate for State Action,” presented at the Association of State and Territorial Health Officers, Washington. D.C.. December 4, 1967.
10
J. Lederberg et al.,
Emerging Infections: Microbial Threats to Health in the United States
(Washington. D.C.: National Academy Press, 1992).
Emerging Infections: Microbial Threats to Health in the United States
(Washington. D.C.: National Academy Press, 1992).
11
Further information can be found in: J. D. Watson et al.,
Molecular Biology of the Gene
(4th ed.; Menlo Park. CA: The Benjamin/Cummings Publishing Company, 1987); P. Berg and M. Singer,
Dealing with Genes: The Language of Heredity
(Mill Valley, CA: University Science Books, 1992); and J. D. Watson,
The Double Helix
(New York: New American Library, 1969).
Molecular Biology of the Gene
(4th ed.; Menlo Park. CA: The Benjamin/Cummings Publishing Company, 1987); P. Berg and M. Singer,
Dealing with Genes: The Language of Heredity
(Mill Valley, CA: University Science Books, 1992); and J. D. Watson,
The Double Helix
(New York: New American Library, 1969).
12
F. J. Fenner et al.,
The Biology of Animal Viruses
(New York: Academic Press, 1968).
The Biology of Animal Viruses
(New York: Academic Press, 1968).
13
For excellent renditions of the history of antibiotics and controversies concerning the rise of bacterial resistance to the chemicals, the reader is referred to two highly readable books: M. Lappé,
Germs That Won't Die
(Garden City, NY: Anchor Press, 1982); and S. B. Levy.
The Antibiotic Paradox
(New York: Plenum Press, 1992).
Germs That Won't Die
(Garden City, NY: Anchor Press, 1982); and S. B. Levy.
The Antibiotic Paradox
(New York: Plenum Press, 1992).
14
J. Lederberg and E. M. Lederberg, “Replica Plating and Indirect Selection,”
Journal of Bacteriology
63 (1952): 399â406.
Journal of Bacteriology
63 (1952): 399â406.
15
Webster's New Twentieth Century Dictionary Unabridged
(New York: Collins World, 1975).
(New York: Collins World, 1975).
16
J. Farley, “Parasites and the Germ Theory of Disease,” in
Framing Disease
, eds. C. E. Rosenberg and J. Golden (New Brunswick, NJ: Rutgers University Press, 1992), 33â49.
Framing Disease
, eds. C. E. Rosenberg and J. Golden (New Brunswick, NJ: Rutgers University Press, 1992), 33â49.
17
Among the monkey species known to serve as malaria reservoirs in Africa, Asia, and South America are
P. knowlesi, P. cynomolgi, P. brasilianum, P. invi, P. scwetzi, and P. simium.
P. knowlesi, P. cynomolgi, P. brasilianum, P. invi, P. scwetzi, and P. simium.
18
Two well-organized, excellent texts provide a quick thumbnail description of all infectious diseases prominent on the planet at this time. Both provide basic information on the hosts, reservoirs, and life cycles of parasites. The reader is referred to A. S. Benenson, ed.,
Control of Communicable Diseases in Man
(15th ed.; Washington, D.C.: American Public Health Association, 1990); and M. E. Wilson,
A World Guide to Infections: Diseases, Distribution, Diagnosis
(Oxford, Eng.: Oxford University Press, 1991).
Control of Communicable Diseases in Man
(15th ed.; Washington, D.C.: American Public Health Association, 1990); and M. E. Wilson,
A World Guide to Infections: Diseases, Distribution, Diagnosis
(Oxford, Eng.: Oxford University Press, 1991).
19
T. McKeown,
The Origins of Human Disease
(Oxford, Eng.: Basil Blackwell, 1988), 52.
The Origins of Human Disease
(Oxford, Eng.: Basil Blackwell, 1988), 52.
20
W. H. McNeill,
Plagues and Peoples
(New York: Doubleday, 1976), 103.
Plagues and Peoples
(New York: Doubleday, 1976), 103.
21
F. Fenner, D. A. Henderson, I. Arita, et al.,
Smallpox and Its Eradication
(Geneva: World Health Organization, 1988).
Smallpox and Its Eradication
(Geneva: World Health Organization, 1988).
22
Smallpox is a relatively recent human disease, seeming to have arisen in India less than 2,000 years ago. In ancient times medical observers could not clearly discriminate between smallpox and other human-to-human epidemic diseases such as measles, bubonic plague, and typhus. As a result, controversy reigns over modern interpretations of ancient medical records.
Nevertheless, several major epidemics that claimed a quarter to a third of the affected populations were, according to historians familiar with medical records, likely to have been smallpox. These include:
| Epidemic Site | Year | |
|---|---|---|
| China | A.D. | 49 |
| Rome | 165 | |
| Cyprus | 251â66 | |
| Greece | 312 | |
| Japan | 552 | |
| Mecca | 569â71 | |
| Arabia | 683 | |
| Europe, various sites | 700â800 |
Compiled from A. Patrick, “Diseases in Antiquity: Ancient Greece and Rome,” in D. Brothwell and A. T. Sandison, eds.,
Diseases in Antiquity
(Springfield. IL: Charles C Thomas, 1967), 238â46; R. Hare, “The Antiquity of Diseases Caused by Bacteria and Viruses: A Review of the Problem from a Bacteriologist's Point of View,” ibid., 115â31; and McNeill (1977), op. cit., 2, 103, 118, 124.
Diseases in Antiquity
(Springfield. IL: Charles C Thomas, 1967), 238â46; R. Hare, “The Antiquity of Diseases Caused by Bacteria and Viruses: A Review of the Problem from a Bacteriologist's Point of View,” ibid., 115â31; and McNeill (1977), op. cit., 2, 103, 118, 124.
23
W. M. Denevan,
The Native Population of the Americas in 1492
(Madison: University of Wisconsin Press, 1992).
The Native Population of the Americas in 1492
(Madison: University of Wisconsin Press, 1992).
Smallpox may have been the most useful weapon of biological warfare in world history. European colonialists repeatedly took advantage of the special susceptibility of the Amerindian population, deliberately spreading the deadly virus among Indians who were successfully defending their rights to the lands and resources of the Americas. For example, in 1763 Sir Jeffrey Amherst, commander in chief of all British forces in North America, was having great difficulty controlling the Pontiac Indians in the western territories. At Amherst's insistence, blankets inoculated with live smallpox viruses were distributed to the Pontiac, obliterating the tribe. The deliberately induced epidemic quickly spread to the northwest, claiming large numbers of Sioux and Plains Indians, crossed the Rookies and inflicted huge death tolls among Native Americans from southern California all the way north to the Arctic Circle tribes of Alaska. This devastation was cited in the official WHO history of smallpox: Fenner, Henderson, Arita, et al., (1988), op. cit.
24
Fenner, Henderson, Arita, et al. (1988), op. cit.
25
English physician Edward Jenner discovered in 1796 that cowpox, which was harmless to people, could be used as a vaccine against smallpox. The riskier idea of inoculating people with small amounts of human smallpox to raise immunity goes back in some cultures to ancient times, although some people developed the disease after injection. The British royal family was so immunized in 1722,
as was the entire American Revolutionary Army under the command of General George Washington in 1776.
as was the entire American Revolutionary Army under the command of General George Washington in 1776.
26
Spectacular accounts of the smallpox campaign can be found in June Goodfield's
Quest for
Killers (Boston: Birkhauser, 1985), 191â244; and Horace G. Ogden's
CDC and the Smallpox Crusade,
HHS Publication No. (CDC)87â8400 (Washington, D.C.: U.S. Government Printing Office, 1987).
Quest for
Killers (Boston: Birkhauser, 1985), 191â244; and Horace G. Ogden's
CDC and the Smallpox Crusade,
HHS Publication No. (CDC)87â8400 (Washington, D.C.: U.S. Government Printing Office, 1987).
27
In Ghana, for example, there were at least six major smallpox epidemics between 1901 and 1960, and in some the mortality rate among those infected with the virus was a staggering 50 percent. Whole villages were decimated, and the disease disrupted the national economy. Yet in no year were more than 1,950 cases registered in federal records. See D. Scott,
Epidemic Disease in Ghana 1901â1960
(London: Oxford University Press, 1965), 65â84.
Epidemic Disease in Ghana 1901â1960
(London: Oxford University Press, 1965), 65â84.
28
In 1978 two people in Birmingham, England, contracted smallpox as a result of a laboratory accident. The Birmingham laboratory illegally possessed smallpox samples, and lab photographer Janet Parker died as a result of a containment failure. Her mother also was infected, but survived. Today samples of the two types of smallpox exist in just two high-security laboratories: the CDC's Atlanta lab and a Moscow facility. The CDC is currently sequencing the entire genetic code of the more dangerous variola major virus. And Moscow scientists are sequencing the less lethal variola minor form. By international agreement, both the Atlanta and Moscow smallpox samples are scheduled to be destroyed when gene sequencing is complete, although the elimination of all surviving viruses is a matter of considerable controversy.
29
The real 1991 dollar values of historic public health programs were derived using the latest United States CPI data, found in U.S. Department of Labor,
Consumer Price Index, Detailed Report
(Washington, D.C.: U.S. Government Printing Office, February 1992).
Consumer Price Index, Detailed Report
(Washington, D.C.: U.S. Government Printing Office, February 1992).
In 1991 dollars, the smallpox eradication effort cost $759.5 million, still a remarkably low cost when compared with the hundreds of billions now expended worldwide annually to combat just three diseases: AIDS, cancer, and heart disease.
30
Thirty-third World Health Assembly,
Declaration of Global Eradication of Smallpox,
Geneva, May 8, 1980.
Declaration of Global Eradication of Smallpox,
Geneva, May 8, 1980.
31
U.S. Department of Labor. (1992), op. cit.
32
Ibid.
33
Institute of Medicine,
Malaria: Obstacles and Opportunities
, eds. S. C. Oates et al. (Washington, D.C.: National Academy Press, 1991).
Malaria: Obstacles and Opportunities
, eds. S. C. Oates et al. (Washington, D.C.: National Academy Press, 1991).
34
DDT is dichloro-diphenyl-trichloroethane. Its insecticidal properties were discovered in 1939 by Swiss researcher Paul Müller, who received the 1948 Nobel Prize in medicine for his efforts. In the following years chemists developed several sister compounds that were also potent organochlorines, including dieldrin, chlordane, heptachlor, aldrin, and endrin. None was as effective in killing
Anopheles
mosquitoes as was DDT.
Anopheles
mosquitoes as was DDT.
A second class of insecticides, organophosphates, was developed by the German Third Reich as nerve gases. It was discovered after World War II that these compounds could block crucial enzymes in insects, and parathion, malathion, and related chemicals came into use. Because of their acute human toxicity, the organophosphates were not widely used for malaria control in the 1950s and 1960s.
35
G. R. Coatney, “Simian Malarias in Man: Facts, Implications, and Predictions,”
American Journal of Tropical Medicine and Hygiene
17 (1968): 147â55.
American Journal of Tropical Medicine and Hygiene
17 (1968): 147â55.
36
General Douglas MacArthur, who led Allied operations in the World War II Pacific theater, said, “This will be a long war, if for every division I have facing the enemy, I must count on a second division in the hospital with malaria, and a third division convalescing from this debilitating disease.”
See P. F. Russell, C. S. West, and R. D. Manwell,
Practical Malariology
(Philadelphia: W. B. Saunders, 1946); and W. Hockmeyer, personal interview, Walter Reed Army Institute of Research, Washington, D.C., September 1986.
Practical Malariology
(Philadelphia: W. B. Saunders, 1946); and W. Hockmeyer, personal interview, Walter Reed Army Institute of Research, Washington, D.C., September 1986.
37
Institute of Medicine (1991), op. cit.
38
Several species of mosquitoes are capable of carrying malarial parasites, but
A. gambiae
is the best suited to spreading the disease.
A. gambiae
is the best suited to spreading the disease.
39
IDAB later became the U.S. Agency for International Development, or US AID.
40
Anonymous,
Malaria Eradication: Report and Recommendations of the International Development Advisory Board, April 13, 1956
(Washington, D.C.: ICA).
Malaria Eradication: Report and Recommendations of the International Development Advisory Board, April 13, 1956
(Washington, D.C.: ICA).
41
About $103.7 million in 1991 dollars. See U.S. Department of Labor, op. cit.
42
A. Spielman, U. Kitron, and R. J. Pollack, “Time Limitation and the Role of Research in the Worldwide Attempt to Eradicate Malaria,”
Journal of Medical Entomology
30 (1993): 6â19; and J. A. Najera, “Malaria and the Work of WHO,”
Bulletin of the World Health Organization
67 (1989): 229â43.
Journal of Medical Entomology
30 (1993): 6â19; and J. A. Najera, “Malaria and the Work of WHO,”
Bulletin of the World Health Organization
67 (1989): 229â43.
43
Written in deceptively simple prose,
Silent Spring
raised havoc when it was released in 1962,
spawning the contemporary environmental movement and massive public outcry about the ecological destruction caused by improper pesticide use. The importance of Carson's book cannot be overstated: it was to the budding environmental movement what Charles Darwin's
Origin of the Species
was to evolution. Many have credited her book and the movement it started for the institution of environmental regulatory systems and laws in nations throughout the Western world.
Silent Spring
raised havoc when it was released in 1962,
spawning the contemporary environmental movement and massive public outcry about the ecological destruction caused by improper pesticide use. The importance of Carson's book cannot be overstated: it was to the budding environmental movement what Charles Darwin's
Origin of the Species
was to evolution. Many have credited her book and the movement it started for the institution of environmental regulatory systems and laws in nations throughout the Western world.
Other books
The Archimedes Effect by Tom Clancy
Bootstrapper: From Broke to Badass on a Northern Michigan Farm by Link, Mardi Jo
THEM (Season 1): Episode 3 by Massey, M.D.
Breanna by Karen Nichols
Unnecessary Roughness by G.A. Hauser
Studying Boys by Stephie Davis
The Road to McCarthy by Pete McCarthy
A Matter of Honor (Privateer Tales Book 9) by Jamie McFarlane
THE MAGICAL PALACE by Mukjerjee, Kunal
The Japanese Ninja Surprise by Jeff Brown
