Read The Mediterranean Zone Online
Authors: Dr. Barry Sears
Nathan C and Ding A. “Nonresolving inflammation.” Cell 140: 871–882 (2010)
Prior RL, Cao G, Prior RL, and Cao G. “Analysis of botanicals and dietary supplements for antioxidant capacity: a review.” J AOAC Int 83: 950–956 (2000)
Scapagnini G, Vasto S, Abraham NG, Caruso C, Zella D, and Fabio G. “Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders.” Mol Neurobiol 44: 192–201 (2011)
Scholz S and Williamson G. “Interactions affecting the bioavailability of dietary polyphenols in vivo.” Int J Vitam Nutr Res 77: 224–235 (2007)
Sears B.
The Anti-Aging Zone.
Regan Books. New York, NY (1999)
Spite M, Claria J, and Serhan CN. “Resolvins, specialized proresolving lipid mediators and their potential roles in metabolic diseases.” Cell Metabolism 19: 21–36 (2014)
Wallace SS. “Biological consequences of free radical-damaged DNA bases.” Free Radic Biol Med 33: 1–14 (2002)
Zhang MJ and Spite M. “Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids.” Annu Rev Nutr 32: 203–227 (2012)
U.S. FDA. “FDA expands advice on statin risk.”
www.fda.gov/forconsumers/consumerupdates/ucm293330.htm#2
Anderson RM and Weindruch R. “Metabolic reprogramming, caloric restriction and aging.” Trends Endocrinol Metab 21: 134–141 (2010)
Ayissi VB, Ebrahimi A, and Schluesenner H. “Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms.” Mol Nutr Food Res 58: 22–32 (2014)
Bao Y, Han J, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, and Fuchs SC. “Association of nut consumption with total and cause-specific mortality.” N Engl J Med 369: 2001–2011 (2013)
Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH and EB. “High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women.” Circulation 127: 188–196 (2013)
Chang HC and Guarente L. “SIRT1 and other sirtuins in metabolism.” Trends Endocrinol Metab 25: 138–145 (2014)
Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, and Rahman I. “Regulation of SIRT1 in cellular functions: role of polyphenols.” Arch Biochem Biophys 501: 79–90 (2010)
Fontana L. “The scientific basis of caloric restriction leading to longer life.” Curr Opin Gastroenterol 25: 144–150 (2009)
Goldman DP, Cutler D, Rowe JW, Michaud P, Sullivan, J, Peneva K, and Olshansky SJ. “Substantial health and economic returns from delayed aging may warrant a new focus for medical research.” Health Affairs 32: 1698–1705 (2013)
Holloszy JO and Fontana L. “Caloric restriction in humans.” Exp Gerontol 42: 709–712 (2007)
Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, and Zang M. “SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.” J Biol Chem 283: 20015–20026 (2008)
Hwang JT, Kwon DY, and Yoon SH. “AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols.” Nature Biotechnol 26: 17–22 (2009)
McCay CM, Crowell MF, Maynard LA. “The effect of retarded growth upon the length of life span and upon the ultimate body size.” J Nutr 10: 63–79 (1935)
Sears B.
The Anti-Aging Zone
. Regan Books. New York, NY (1999)
Tennen RI, Michishita-Kioi E,and Chua KF. “Finding a target for resveratrol.” Cell 148: 387–389 (2012)
Tollefsbol T (ed).
Epigenetics in Human Disease
. Academic Press. New York, NY (2012)
Zamora-Ros R, Rabassa M, Cherubini A, Urpí-Sardà M, Bandinelli S, Ferrucci L, Andres-Lacueva C. “High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults.” J Nutr 143: 1445–1450 (2013)
Avena NM, Rada P, and Hoebel BG. “Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake.” Neurosci Biobehav Rev 32: 20–39 (2008)
Bachmanov AA and Beauchamp GK. “Taste receptor genes.” Annu Rev Nutr 27: 389–414 (2007)
Breslin PA and Beauchamp GK. “Salt enhances flavour by suppressing bitterness.” Nature 387: 563 (1997)
Irie F, Fitzpatrick AL, Lopez OL, Kuller LH, Peila R, Newman AB, and Launer LJ. “Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study.” Arch Neurol 65: 89–93 (2008)
Lenoir M, Serre F, Cantin L, and Ahmed SH. “Intense sweetness surpasses cocaine reward.” PLoS ONE 2: e698 (2007)
Mehla J, Chauhan BC, and Chauhan NB. “Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits.” J Alzheimer’s Dis 39: 145–162 (2014)
Moss M.
Salt Sugar Fat: How the Food Giants Hooked Us.
Random House, NY (2013)
Mozaffarian D, Pischon T, Hankinson SE, Rifai N, Joshipura K, Willett WC, and Rimm EB. “Dietary intake of trans fatty acids and systemic inflammation in women.” Am J Clin Nutr 79: 606–612 (2004)
Mozaffarian D, Aro A, and Willett WC. “Health effects of trans-fatty acids: experimental and observational evidence.” Eur J Clin Nutr 63: S5–21 (2009)
Profenno LA, Porsteinsson AP, and Faraone SV. “Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders.” Biol Psychiatry 67: 505–512 (2010)
Siri-Tarino PW, Sun Q; Hu FB, and Krauss RM. “Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.” Am J Clin Nutr 91: 535–546 (2010)
Spangler R, Wittkowski KM, Goddard NL, Avena NM, Hoebel BG, and Leibowitz SF. “Opiate-like effects of sugar on gene expression in reward areas of the rat brain.” Brain Res Mol Brain Res 124: 134–142 (2004)
Spetter MS, Smeets PA, de Graaf C, and Viergever MA. “Representation of sweet and salty taste intensity in the brain.” Chem Senses 35: 831–840 (2010)
Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y. Dai M, Lu J, Xu M, Li Y, Hu N, Li J, Mi S, Chen CS, Li G, Mu Y, Zhao J, Kong L, Chen J, Lai S, Wang W, Zhao W, and Ning G. “Prevalence and control of diabetes in Chinese adults.” JAMA 310: 948–959 (2013)
Zhu X, Tang X, Anderson VE, and Sayre LM. “Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid.” Chem Res Toxicol 22: 1386–1397 (2009)
American Heart Association. “Dietary guidelines for healthy American adults.” Circulation 77: 721A–724A (1988)
Berg JM, Tymoczko JL, and Stryer L.
Biochemistry, 5th edition
. W.H. Freeman. New York, NY (2002)
Beguin P, Errachid A, Larondelle Y, and Schneider YJ. “Effect of polyunsaturated fatty acids on tight junctions in a model of the human intestinal epithelium under normal and inflammatory conditions.” Food Funct 4: 923–931 (2013)
Brouns F, van Buul VJ, and Shewry PR. “Does wheat make us fat and sick?” J Cereal Sci 58: 209–213 (2013)
Bray GA, Nielsen SJ, and Popkin BM. “Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity.” Am J Clin Nutr 79: 537–543 (2004)
Butterwoth T. “Sweet and Sour: The media decided fructose was bad for America, but science had second thoughts.” Forbes February 6, 2014 (2014)
Carden TJ and Carr TP. “Food availability of glucose and fat, but not fructose, increased in the US between 1970 and 2009.” Nutr J 12: 130 (2013)
Cavalli-Sforza LT, Strata A, Barone A, and Cucurachi L. “Primary adult lactose malabsorption in Italy: regional differences in prevalence and relationship to lactose intolerance and milk consumption.” Am J Clin Nutr 45: 748–754 (1987)
Cook HW. “The influence of trans-acids on desaturation and elongation of fatty acids in developing brain.” Lipids 16: 920–926 (1981)
Cook HW and Emken EA. “Geometric and positional fatty acid isomers interact differently with desaturation and elongation of linoleic and linolenic acids in cultured glioma cells.” Biochem Cell Biol 68: 653–660 (1990)
Crittenden RG and Bennett LE. “Cow’s milk allergy: A complex disorder.” Journal of the American College of Nutrition 24: 582S–591S (2005)
Cruz-Teno C, Perez-Martinez P, Delgado-Lista J, Yubero-Serrano EM, Garcia-Rios A, Marin C, Gomez P, Jimenez-Gomez Y, Camargo A, Rodriguez-Cantalejo F, Malagon MM, Perez-Jimenez F, Roche HM, and Lopez-Miranda J. “Dietary fat modifies the postprandial inflammatory state in subjects with metabolic syndrome: the LIPGENE study.” Mol Nutr Food Res 56: 854–865 (2012)
Davis JE, Gabler NK, Walker-Daniels J, and Spurlock ME. “TLR-4 deficiency selectively protects against obesity induced by diets high in saturated fat.” Obesity 16: 1248–1255 (2008)
Davis W.
Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health.
Rodale Books. Erasmus, PA (2011)
de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, and Delaye J. “Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease.” Lancet 343: 1454–1459 (1994)
de Lorgeril M. Salen P, Martin JL, Monjaud I, Delaye J, and Mamelle N. “Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study.” Circulation 99: 779–785 (1999)
Ghosh S, Mocan E, DeCoffe D, Dai C, and Gibson D. “Diets rich in n-6 PUFA induce intestinal microbioal dysbiosis in aged mice.” Brit J Nutr 110: 515–523 (2013)
Fasano A.
Gluten Freedom: The Nation’s Leading Expert Offers the Essential Guide to a Healthy, Gluten-Free Lifestyle.
Wiley. New York, NY (2014)
Ebbeling CB, Swain JF, Feldman HA, Wong WW, Hachey DL, Garcia-Lago E, and Ludwig DS. “Effects of dietary composition on energy expenditure during weight-loss maintenance.” JAMA 307: 2627–2634 (2012)
Enos RT, Davis JM, Velazquez KT, McClellan JL, Day SD, Carnevale KA, and Murphy EA. “Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters.” J Lipid Res 54: 152–163 (2013)
Kennedy A, Martinez K, Chuang C, LaPost K, and McIntosh M. “Saturated fatty acid-mediated inflammation and insulin resistance in the adipose tissue.” J Nutr 139: 1–4 (2009)
Kien CL, Bunn JY, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, and Muoio DM. “Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.” Am J Clin Nutr 97: 689–697 (2013)
Kuipers RS, de Graaf DJ, Luxwolda MF, Muskiet MH, Dijck-Brouwer DA, and Muskiet FA. “Saturated fat, carbohydrates and cardiovascular disease.” Neth J Med 69: 372–378 (2011)
Klurfeld DM, Foreyt J, Angelopoulos TJ, and Rippe JM. “Lack of evidence for high fructose corn syrup as the cause of the obesity epidemic.” Int J Obes 37: 771–773 (2013)
Harris WS, Mozaffarian D, Rimm E, Kris-Etherton P, Rudel LL, Appel LJ, Engler MM, Engler MB, and Sacks F. “Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention.” Circulation 119: 902–907 (2009)
Hill EG, Johnson SB, Lawson LD, Mahfouz MM, and Holman RT. “Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil.” Proc Natl Acad Sci USA 79: 953–957 (1982)
Holt SHA, Brand-Miller JC, and Petocz. “An insulin index of foods.” Am J Clin Nutr 66: 1264–1276 (1997)
Hoyt G, Hickey MS, and Cordain L. “Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk.” Br J Nutr 93: 175–177 (2005)
Host A. “Frequency of cow’s milk allergy in childhood.” Ann Allergy Asthma Immunol 89: 33–37 (2002)
Hokayem M, Blond E, Vidal H, Lambert K, Meugnier E, Feillet-Coudray C, Coudray C, Pesenti S, Luyton C, Lambert-Porcheron S, Sauvinet V, Fedou C, Brun JF, Rieusset J, Bisbal C, Sultan A, Mercier J, Goudable J, Dupuy AM, Cristol JP, Laville M, and Avignon A. “Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.” Diabetes Care 2013 36: 1454–1461 (2013)
Jayashree B, Bibin YS, Prabhu D, Shanthirani CS, Gokulakrishnan K, Lakshmi BS, Mohan V, and Balasubramanyam M. “Increased circulatory levels of lipopolysaccharide (LPS)
and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes.” Mol Cell Biochem 388: 203–210 (2014)
Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets.” Am J Clin Nutr 83: 1055–1061 (2006)
Liebman B. “The changing American diet.” Nutritional Action Newsletter. September, 2013 (
http://cspinet.org/new/pdf/changing_american_diet_13.pdf
) (2013)
Lopez-Garcia E, Schulze MB, Meigs JB, Manson JE, Rifai N, Stampfer MJ, Willett WC, and Hu FB. “Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.” J Nutr 135: 562–566 (2005)
Lopez S, Bermudez B, Ortega A, Varela LM, Pacheco YM, Villar J, Abia R, and Muriana FJ. “Effects of meals rich in either monounsaturated or saturated fat on lipid concentrations and on insulin secretion and action in subjects with high fasting triglyceride concentrations.” Am J Clin Nutr 93: 494–499 (2011)
Lowndes J, Kawiecki D, Pardo S, Nguyen V, Melanson KJ, Yu Z, and Rippe JM. “The effects of four hypocaloric diets containing different levels of sucrose or high fructose corn syrup on weight loss and related parameters.” Nutr J 11: 55 (2012)
Lustig RH.
Fat Chance: Beating the Odds Against Sugar, Processed Food, Obesity, and Disease
. Hudson Street Press. New York, NY (2012)
Maric T, Woodside B, and Luhenshi GN. “The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats.” Brain Behave Immun 36: 35–45 (2014)